Presentations at the 2019 AACR Annual Meeting

Upcoming oral and poster presentations for the American Association for Cancer Research (AACR) annual meeting to be held in Atlanta, Georgia from March 29 - April 3, 2019.


Mitochondrial Function and Metabolism in Cancer

March 29, 2019

Multi-targeted novel 5-substituted pyrrolo[3,2-d]pyrimidines with tumor-selective targeting and inhibition of cytosolic de novo purine biosynthesis and mitochondrial one-carbon metabolism. Read Abstract

Novel Antitumor Agents

April 3rd, 2019

Targeting mitochondrial and cytosolic one-carbon metabolism in epithelial ovarian cancer via folate receptor alpha. Read Abstract

Targeting mitochondrial and cytosolic one carbon metabolism of pancreatic adenocarcinoma via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine analogs. Read Abstract

Impact of folate transport redundancies on the therapy with tumor-targeted and untargeted antifolates. Read Abstract

Diagnostics, Biomarkers, and the Tumor Microenvironment

April 3rd, 2019

Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates. Read Abstract

Aaron White